More Evidence That Broccoli Protects Against Breast Cancer
I was checking out the latest research today on www.pubmed.gov (one of my favorite places to troll for breast cancer research) and came across an article titled “Dietary Chemopreventative Benzyl Isothiocyanate Inhibits Breast Cancer Stem Cells In Vitro and In Vivo“, authored by Su-Hyeong Kim, Anuradha Sehrawat, Shivendra V. Singh et al from the Dept of Pharmacology & Chemical Biology, University of Pittsburgh. The article will be published in the May 2013 issue of Cancer Prevention Research, by the American Association for Cancer Research.
Broccoli Wins Again
Knowing that benzyl isothiocyanate is a naturally occurring compound found in cruciferous vegetables, I latched onto the article and did my best to decipher it (which ain’t easy when you’re not a scientist!). Here’s what I gleaned from the article.
The researchers reported that a small subset of mammary tumor initiating cells (also known as breast cancer stem cells or bCSC) are suspected to evade conventional therapies, often leading to disease recurrence, and that elimination of not only the tumor cells that were therapy-sensitive, as well as the therapy-resistant breast cancer stem cells, would be necessary for prevention of breast cancer.
The researchers mentioned that they have already proven that benzyl isothiocyanate was effective against the development of breast cancer in mice by causing epithelial tumor cell apoptosis.
In this study the researchers were equally successful at using benzyl isothiocyanate in the diet of the mice with tumors, and resulted in a “marked decrease in breast cancer stem cells”.
Also Protective Against Metastasis
In addition, I found some 2010 Chinese research that indicated benzyl isothiocyanate was also effective in inhibiting the migration and invasion of human colon cancer cells, that the compound has potential as an antimetastatic agent. Exciting!
In the words of Hippocrates, known as the Father of Medicine, “Let Your Food Be Your Medicine”.
There are many vegetables – not just broccoli – in the cruciferous range – read my page “Diet and Cancer” for the full list.
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