Study Shows Curcumin Works As Well As Herceptin In Some Cases
While doing some research for one of my newsletters about curcumin, the pigment derived from the root spice turmeric, and its good effects for breast cancer, I ran across a study on curcumin that had some great information for those with HER2 positive breast cancer.
About 15-25 percent of breast cancer patients are HER2 positive, meaning that their tumors have an overexpression of this oncoprotein which researchers have observed is associated with a poor prognosis, increased disease recurrence and metastases. One of the drugs that has been created to address this problem is trastuzumab, also called Herceptin.
There is little doubt that Herceptin is saving lives, but there’s a problem for some people.
Quite a few women have contacted me from various parts of the world where Herceptin is either not available or too expensive – Africa being the main location where this is happening. These women have been diagnosed with HER2 positive breast cancer and are quite concerned that Herceptin is not available for them. Another couple of problems exist as well. The tumor cells of some women have a resistance to Herceptin. And for some, Herceptin is too hard on their heart and/or lungs. So it is for these women that I am sharing this information.
The study I read was released in 2012 and its title is “The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin” .
As denoted by the title, the study was both an in vitro (test tube) study and in vivo (in body – with animals) study done with various lines of breast cancer cells and on mice. I believe the results are very interesting and are certainly worth considering, especially in view of the fact that not everyone has access to the drug Herceptin, some are resistant and some are just not able to tolerate it. These people need Herceptin alternatives.
Researchers wanted to gain some insight about what worked best for tumors that overexpress the HER2 oncoprotein. So they divided up various lines of breast cancer cells (listed below) in test tubes and also test animals into 8 different groups:
1. Those who received DMSO only
2. Those who received Herceptin only
3. Those who received curcumin only
4. Those who received a combination of Herceptin and curcumin
5. Those who received Taxol only
6. Those who received a combination of Taxol and Herceptin
7. Those who received a combination of Taxol and curcumin
8. Those who received a combination of Taxol, curcumin and Herceptin
The results revealed that curcumin reduced the cell viability of several different breast cancer cell lines, including MCF-7 (ER-positive, HER-2-negative), MDA-MB-231 (ER-negative, PR-negative, HER-2-negative – also known as triple negative), BT-474 (ER-positive, HER-2-positive), and SK-BR-3-hr (ER-negative, HER-2-positive but Herceptin-resistant) cells.
Herceptin Combined with Curcumin
Researchers found that when a low dose of Herceptin was used with curcumin, there was a synergistic effect, but when a high dose of Herceptin was used, there was an antagonistic effect, meaning that the combination didn’t work as well. So for someone having high doses of Herceptin, taking curcumin would most likely not provide an advantage.
In BT-474 cells (ER-positive, HER-2 positive), curcumin effectively decreased tumor size.
Also, researchers noted that curcumin had the ability to inhibit Herceptin-resistant breast cancer cells (SK-BR-3). This is of great importance to those who are HER2 positive but who are resistant to Herceptin. Researchers stated “The ability of curcumin to downregulate EGFR and HER-2 oncoproteins and inhibit the phosphorylation of Akt and MAPK and NF-kB activation suggests that curcumin has potential in the treatment of HER-2-overexpressed and/or herceptin-resistant breast cancer.”
In the animal study, curcumin treatment effectively reduced the tumor size by 76.7%, compared with the control; however, it was not as effective as Herceptin, which achieved an 86.7% tumor reduction.
Did you get that? Curcumin alone reduced tumor size by 76.7%. Yes, Herceptin did a better job, it reduced tumor size by 86.7% but Herceptin is also pretty hard on the body and curcumin is not.
Researchers also revealed that the combination of Herceptin and curcumin showed a greater antitumor effect than curcumin alone (87.5% versus 76.7% in tumor regression).
Interestingly, researchers anticipated the study to reveal that there would be a synergistic effect when combining Herceptin with curcumin, but in the animal study, combining Herceptin and curcumin was no better than Herceptin alone.
Taxol Combined With Curcumin
In the animal study, the combination of curcumin with Taxol had an antitumor effect comparable with combining Taxol and Herceptin, which is one of the current preferred chemotherapy regimens for those with HER2 positive breast cancer. The combination of Taxol, Herceptin and curcumin was associated with the smallest tumors, but was not “statistically different” from that of the Taxol and Herceptin regimen.
I take that last paragraph to mean that combining Taxol with curcumin is just as good as combining Taxol and Herceptin. That’s huge! And combining Taxol, Herceptin and curcumin provided the best results in the animal study.
In conclusion, I believe this study is significant. In people who do not tolerate Herceptin well or are unable to get this drug due to finances or geographical location, or for those whose tumor cells are Herceptin resistant, according to this study, the combination of Taxol and curcumin is just as good as combining Taxol and Herceptin.
2021 Update: We now have a 2020 study  which discusses the fact that previous studies on curcumin and HER2 signalling used extremely high doses of curcumin – doses that might not be attainable for normal human beings. So the researchers set out to see if lower doses of curcumin would also have a good effect. They found that lower concentrations of curcumin (and also quercetin and a berry fruit extract) not only were effective at reducing HER2 signalling, but also worked synergistically with Herceptin to increase the effectiveness of that drug.
For dosage advice of curcumin, see my article: Harvest The Power Of Curcumin To Kill Breast Cancer Cells.
 The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin – http://www.hindawi.com/journals/ecam/2012/486568/
 Lower concentrations of curcumin inhibit Her2-Akt pathway components in human breast cancer cells, and other dietary botanicals potentiate this and lapatinib inhibition – https://pubmed.ncbi.nlm.nih.gov/32563955/
GET MY BEST TIPS on getting through breast cancer and preventing recurrences by signing up for my free e-newsletters and e-books on the right. You can also “like” me on Facebook (Marnie Clark, Breast Health Coach) to get my inspirational snippets, news and updates. I promise to do my utmost to keep you informed and empowered on your healing journey… and beyond.
Very useful and informative; have been supplementing my diet with tumeric for approx 5 years. -AG (HER2 positive and ER positive br cancer survivor)
Thanks for sharing that with us, very inspiring!
Dear Alicia, I’ve the same breast cancer type as you and I’m supplementing with curcumin as well. But I’m not shure if I’m doing it right. Which dose do you take?
@Marnie Great article as usual, thanks a lot! 🙂
Curious, what is considered a high dose of Herceptin? I Go in every three weeks for Herceptin and perjeta. I’ve been on this treatment for 3 years now. (ER-ve, her2+)
I’m not sure. The research I read did not spell that out. Wow – three years is a long time to be on Herceptin. How are you coping with it all?
Dear Alicia, I’ve the same breast cancer type as you and I’m supplementing with curcumin as well. But I’m not sure if I’m doing it right. Which dose do you take?
@Marnie Great article as usual, thanks a lot!
Hi Marnie, I’m on Herceptin. I was on it for a year in 2012. MBC (triple pos. w/HER2) returned in the liver, and after 2 rounds of chemo, I’m on “maintenance” with Herceptin, now for last 2 years. and I’ll be on for the remainder of my life. I am doing very well, and I attribute my well being to exercising/walking/strength training approximately 5 days a week. Although, I now have multiple tumors in the liver, and the Herceptin does not appear to be helping. I just read this article, and bout the Curcumin 500 you recommended. I’ve only been on Curcumin for a week, and wonder if I should take more than 500/day. What was mentioned in the studies for daily intake. Many thanks! Your articles are informative and encouraging. Many thanks for your work.
Thanks for your kind words about my website. Much appreciated. The study I referred to in this article was an animal study – as far as I can see, there have not been human trials with Herceptin and curcumin. The research did not recommend a human daily intake so it is left to us to decipher what is a therapeutic dose. I will refer you to Dr Brian Lawenda, an integrative oncologist. His dosage recommendations are in this article: https://marnieclark.com/harvest-the-power-of-curcumin-to-kill-breast-cancer-cells/ I hope this information helps. You might also like to sign up for my free newsletters, full of the latest research and information. You can do that from any page on my website (over on the far right-hand side). Wishing you much healing, my dear.
I had 3rd stage Triple Neg. spread to LN. Tumors vanished in two months before chemo! I took about 40 pills aday of high dose herbs. Curcumin SAVED my life! I took 5K mg per day. Turkey tail mushroom (in clinical trials) 9K mg aday. Build your immune system is key! Vit d- c zinc -magnesium- resveratrol- oregano- probiotics- selenium. I had a complete path response at lumpectomy. This rarely happens! I amazed ALL the doctors.
Bethanie, thanks for sharing that with us! It’s wonderful when people share their success stories with us. Congrats on getting such a good result, well done. Keep up the good work!
Was reading that metformin resentitizes cancer cells to herceptin
Thanks everyone for the useful info. I just got diagnosed with HER2 positive at age 39.