Tag Archives: DIM

Clarification On DIM And Its Uses For Breast Cancer

 

Photo courtesy of freedigitalphotos.net and M Bartosch
Photo courtesy of freedigitalphotos.net and M Bartosch

Clarification On DIM And Its Uses For Breast Cancer

Back to work!  I’ve been moving from Colorado to Australia, hence the very quiet period on the website.  Just before leaving, I had the opportunity to get some clarification on DIM and its uses for breast cancer from Naturopath Dr Jacob Schor, whose views on various health matters have appeared on this blog previously, most notably in these two articles:

DIM Is Not The Wonder Supplement We’ve Been Led To Believe

More Information On Dim, Estrogen Metabolite Ratios

I was quite upset when I wrote that first article, but I am letting it stay on this site in the event that other women are given the same information about DIM – that it acted like Tamoxifen.  That does not appear to be the case, but it does have some therapeutic value for breast cancer.  Read on.

Once you’ve read the above two articles, and the lengthy article that Dr Schor wrote about estrogen metabolite ratios, you’ll understand better what the issue is with regard to DIM and the old theory of how it supposedly worked.

Basically, natural health care providers have been – for years – recommending the supplement DIM for their patients who have estrogen receptor positive breast cancer but they have been basing their recommendations on a theory that just hasn’t been proven to be true.

Wait!  Don’t Throw The DIM Out Yet!

Dr Schor, in a recent email to me, shared with me the following:  “That theory is used to justify DIM use but we shouldn’t mix the two up.  Just because the theory doesn’t work doesn’t mean that DIM doesn’t work.  Because it seemed to lock in to the theory, all benefits were thought to come from its effect on estrogen metabolites.  I’m not sure that is so but I am also not sure we should throw DIM in the trash.  I think we need to think twice about testing 2 vs 16 metabolite ratios, that we should not think these lab tests are prognostic and we should not be in a rush to move them one way or another.

There seem to be a surplus of interesting papers being published that suggests that DIM does things we want it to do.  There are a growing number of reasons to take it.  There are fewer and fewer reasons to think the 2/16 hydroxy estrogen theory is the reason why it is useful.
 
Dr Schor referred me to the following very interesting articles:

2,2′-diphenyl-3,3′-diindolylmethane: a potent compound induces apoptosis in breast cancer cells by inhibiting EGFR pathway, Bhowmik A, Das N, Pal U, Mandal M, Bhattacharya S, Sarkar M, Jaisankar P, Maiti NC, Ghosh MK, PLoS One. 2013;8(3):e59798. doi: 10.1371/journal.pone.0059798. Epub 2013 Mar 28.

Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethene in human breast epithelial cell lines, Licznerska BE, Szaefer H, Murias M, Bartoszek A, Baer-Dubowska W, Eur J Nutr. 2013 Aug;52(5):1483-92. doi: 10.1007/s00394-012-0455-9. Epub 2012 Oct 23.

BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer, Jiang J, Thyagarajan-Sahu A, Loganathan J, Eliaz I, Terry C, Sandusky GE, Sliva D, Oncol Rep. 2012 Oct;28(4):1139-45. doi: 10.3892/or.2012.1936. Epub 2012 Jul 26.

BreastDefend™ is a product that is readily available in the USA but I’m not aware of it being available in Australia or the UK yet.

Dr Schor advises us: “So don’t throw out the DIM, throw out the reasons why people thought it was good.  It’s not tamoxifen.  It’s not an aromatase inhibitor.  It’s something else.”

Dr Schor’s qualifications are Naturopathic Doctor, Fellow American Board of Naturopathic Oncology, Associate Editor, The Natural Medicine Journal, Board Member and President, Oncology Association of Naturopathic Physicians (www.OncANP.org) and Board Member of the American Association of Naturopathic Physicians (www.naturopathic.org)

 
If you would like my help with getting through breast cancer in an inspiring and ultra-healthy way, please sign up for my free e-newsletters and e-book on the right, or “like” me on Facebook (MarnieClark.com).  It is my honor and my goal to help you through this so that you emerge from breast cancer feeling better than before, thriving!

More Information on DIM, Estrogen Metabolite Ratios

 

Photo courtesy of freedigitalphotos.net and David Castillo Dominici

Image source: freedigitalphotos.net / David Castillo Dominici

Further to my article of December 11, 2012 “Dim Is NOT The Wonder Supplement We’ve Been Led To Believe“, the article written by Dr Jacob Schor, for which we were waiting publication in the Townsend Letter, the Examiner of Alternative Medicine,  has been published and I wanted to share that link with you:  Estrogen Metabolite Ratios: Time For Us To Let Go

Dr Schor is a gifted naturopath in Denver, and is also President of the Oncology Association of Naturopathic Physicians.  Fair warning – the article is not an easy one to read – I suggest you print it out and go put your feet up in a quiet place to digest the information.  It will probably require several readings to fully appreciate what Dr Schor is telling us about estrogen metabolite ratios.

I found the information fairly depressing, because I (and many like me) had been relying on DIM to keep circulating estrogen levels at a safe range without having to resort to the toxicity of Tamoxifen.  Having said that, I really appreciated Dr Schor’s review of the research, and his courage to publish an article that goes against the current thinking.  We need more fine minds like his in this fight.

If you would like my help with getting through breast cancer in an inspiring and ultra-healthy way, please sign up for my free e-newsletters on the right, or “like” me on Facebook (Marnie Clark, Breast Health Coach).  It is my honor and my goal to help you through this.