Category Archives: Breast Cancer and EGFR

Amazon Herb With Potent Anti-Cancer Effects: Graviola

graviola
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Amazon Herb With Potent Anti-Cancer Effects: Graviola

Article updated March 12, 2014

I have been reading some interesting research about a fruit tree from the Amazon rainforest known as graviola – also known as soursop or custard apple. 

Graviola (Annona muricata) is being researched for its anti cancer properties.  It has been shown especially effective against EGFR, an oncogene. 

I was interested to learn that even Memorial Sloan-Kettering Cancer Center published an article about it in the Integrative Medicine section of their website – here’s a link to that article.

Graviola Is Backed By Research

You will be happy to know that graviola is backed by some interesting research.  On the pubmed.gov website I found this 2011 study:

Selective growth inhibition of human breast cancer cells by graviola fruit extract in vitro and in vivo involving downregulation of EGFR expression“.  I know that sounds like a lot of gobble-de-gook, but here’s what it means.

There is an oncogene known as EGFR (that stands for epidermal growth factor receptor).  An oncogene is a gene that has the potential to cause a normal cell to become cancerous.  For those who have this EGFR gene, doctors have given them a poor prognosis because of its resistance to some chemotherapy drugs.  The study showed that graviola fruit extract significantly down-regulated EGFR gene expression and inhibited the growth of breast cancer cells in mice.

I also found this 2013 study:

Anti cancer activity on Graviola, an exciting medicinal plant extract vs various cancer cell lines and a detailed computational study on its potent anti-cancerous leads

And this study done in 2012:

Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism

Human Studies Lacking

It appears that many of the studies were either performed on mice or in test tubes (in vitro), and some used extracts from the fruit, while others used other parts of the tree – the leaves, the bark, etc. 

We still need a standardized trial on humans before we can get truly excited about the anti cancer properties of graviola, but it certainly bears watching.  I do have a good source in the USA for the leaves of the graviola tree, so contact me if you need that information.

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