Unusual Help For Radiation Dermatitis

 

Photo courtesy of morgueFile / cohdra
Photo courtesy of morgueFile / cohdra

 

Unusual Help For Radiation Dermatitis

Anyone who has gone through radiation therapy for breast cancer understands the meaning of the term “radiation dermatitis”.  By the time the treatment has ended, the patient can have a few nasty side effects ranging anywhere between a mild sunburn to severe and painful ulcerations of the skin.  Some unlucky patients even suffer from radiation necrosis, where the skin of the radiated area actually dies off, creating a hardened and painful area which can take quite some to heal properly.

I don’t share that with you to frighten you, but only to inform because if you are proactive you can definitely ease the discomfort and even hasten your healing time.

What Causes Radiation Dermatitis?

Radiotherapy, also known as radiation oncology, is a form of cancer treatment generally paired with chemotherapy and surgery.  The treatment consists of  beams of radiation being focused onto a tumor (or tumor site if it has been removed), the goal being to kill any malignant cells.  Because the radiation must first pass through the skin, the skin’s quickly dividing cells become damaged as a result.  Radiation dermatitis first presents as a patch of irritation resembling a sunburn. In most cases, healing occurs within weeks of the end of radiotherapy, though some patients report that the skin discoloration remains for many years.

As one radiation oncologist describes it, “Radiation causes skin to fail to reproduce properly, and thus as you ‘use up’ your normal skin, like we all do all day, there are no new layers of skin coming up from the bottom. So eventually the area can ulcerate. This might look like a thermal burn, but it has very little in common with a thermal burn, and the treatments for thermal burns will not help much.” (I’m sorry, I’ve lost the name of the doctor who shared this information.)

Dr Schor Shares Some Research on Bleach Baths for Radiation Dermatitis

Whenever I hear of some new tidbit of information about something assisting radiation dermatitis, I do try to share it.  This time, it comes from Denver-based naturopath, Jacob Schor, ND, FABNO (who is often quoted in this website).  Dr Schor shared this information in a newsletter dated January 14, 2014:

A study published in November 2013 suggests something rather peculiar, that exposure to very dilute laundry bleach may protect against radiation dermatitis.  If you’ve ever followed a cancer patient as they went through radiation treatment, you know what radiation dermatitis is.  Radiation damages the skin, causing what might be less euphemistically described as causing an industrial sunburn, or more accurately as producing human jerky.  Bleach may prevent this from happening, at least to some extent.

A dermatologist named Thomas Leung from Stanford University reported on a pair of trials bathing mice in diluted bleach (hypochlorite). Dilute bleach baths have been used for years to treat eczema, without anyone really knowing why they helped.

One theory was that bleach, being antimicrobial, killed off bacteria that were causing the eczema. A 2009 paper by Amy Paller et al suggests that bleach baths are effective at lowering Staph aureus populations on the skin.[1]    While this sounds like a plausible explanation, there is debate and many consider the bleach dilutions used too weak to have any antibacterial effect.

Really dilute bleach is used to treat eczema, 0.005% sodium hypochlorite, or about one part laundry bleach to 1000 parts water. Leung offers a different explanation for the benefit of bleach.  His research group first examined how diluted bleach affects inflammation; eczema is after all inflammation.

The researchers first examined the effect bleach has on Nuclear factor-kappaB (NF-kB ).  This signaling protein triggers the recruitment of inflammatory cells to sites of infection. Leung’s team exposed human skin cells to the bleach dilution used to treat eczema for an hour and found it blocked NF-kB signaling. The bleach oxidizes the molecule responsible for activating NF-kB and so stops the inflammatory cascade from being initiated. By blocking this activator, the bleach inhibits the NF-kB inflammatory pathway.

This is ever so interesting and opens multiple possibilities.  NF-kB is kind of the common denominator of most inflammatory reactions; it ‘regulates cellular responses to inflammation and aging, and alterations in NF-kB signaling underlie the pathogenesis of multiple human diseases.’

Leung’s team tried dilute bleach on mice to see if it changed radiation dermatitis, as this reaction is instigated by NF-kB. They also tried bleach on the ageing skin of healthy but old mice.

In the radiation experiment, the mice were placed in either a dilute bleach bath or a water bath for 30 minutes daily for ten days prior to radiation treatment. The radiation burns on these ‘bleached’ mice were milder and healed faster than those on the mice who had only been exposed to water baths.

Similar benefits were seen in the old mice.  Daily bleach baths ‘… increased skin cell production resulting in thicker, younger-looking skin than old mice that took plain water baths. In addition, they had lower expression of two genes classically associated with aging.  The effect was short lived, however. The rejuvenated skin returned to its elderly look after about two weeks because the action of bleach on NF-kB is mild, and diminishes with time.’ [2,3]

This might be a surprisingly simple way to reduce radiation dermatitis.  Nasty skin reactions can force postponement of radiation treatment and reduce its effectiveness at preventing cancer recurrence.  Preventing the skin reactions might improve long-term survival.

Bleach may do more than prevent these skin reactions in cancer patients.  NF-kB  ‘plays a critical role in cancer development and progression’ and is a ‘key pathway in activation of immune responses’ and this ‘activation may also affect the cancer’s response to therapy, making it less susceptive to radio and chemo treatment.’ [4]

We already encourage cancer patients to take many of the supplements that lower NF-kB .  These include green tea [5] , curcumin [6,7], quercetin [8-10], nigella sativa, [11] resveratrol  and other polyphenols [12].  A daily dip in the bleach might help cancer patients in other ways.

This study draws my attention because it is so counterintuitive.  It is backwards from what you would think.  Bleach is a nasty caustic oxidant. It should hurt, not help.

One way to understand this is to see this as an example of hormesis. In toxicology, hormesis refers to the phenomenon in which a graph of a substance’s toxic effects takes on a j-shaped or u-shaped curve.    Low doses can sometimes produce the opposite effect of higher doses.  It is like homeopathy’s Law of Similars, just skip the infinitesimal dilutions where there is nothing left except good vibrations..   Concentrated bleach will burn the dickens out of your skin, but in tiny amounts, bleach will protect and heal the skin.

Understanding hormesis may be key to our understanding other therapies we employ in naturopathy.  Many of the phytochemicals we value so much are toxins produced by plants for self-protection.  Curcumin, resveratrol, quercetin and other  of our valued phytochemicals are actually insecticides, anti-fungals and neurotoxins.  Plants make them to ward off predators and kill infectious microbes.  When we use them, it is for their hormetic action.  Exposure triggers an adaptive response in the body recruiting resources to neutralize potential injury.

So what exactly is a 0.005% hypochlorite bleach solution?  Generic bleach is typically about 3-6% sodium hypochlorite.  To reach this dilution one would dilute one-part bleach with about 1,000 parts water.  An average bathtub contains about 100 liters of water, more or less, so a tenth of a liter or 100 ml of bleach, (3.4 oz or about half a cup) would produce approximately this dilution.  Of course bathtubs vary greatly in size, but this gives you an approximate idea.

This is close to the dilution that various websites suggest to treat eczema. The National Eczema Association[13]  and the American Academy of Allergy, Asthma and Immunology both suggest ¼ to ½ cup. [14]

While these data come from animal experiments, there seems to be little risk in translating them into treatment protocols for people.  As mentioned bleach baths are already used to treat eczema.  It seems easy enough to incorporate them into a treatment for cancer patients as well.

References:

1. Huang JT, Abrams M, Tlougan B, Rademaker A, Paller AS. Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity. Pediatrics. 2009 May;123(5):e808-14. doi: 10.1542/peds.2008-2217.

2.   Alyssa Botelho. Vastly diluted bleach may have protective effect on skin. New Scientist:18:28 15 November 2013.

3.  Leung TH, Zhang LF, Wang J, Ning S, Knox SJ, Kim SK. Topical hypochlorite ameliorates NF-κB-mediated skin diseases in mice. J Clin Invest. 2013 Dec 2;123(12):5361-70. Full text: 10.1172/JCI70895

4.  Berkovich L, Ron I, Earon G, Abu-Ghanem S, Rimmon A, Lev-Ari S. [The role of medicinal herbs with anti-inflammatory properties in prevention and treatment of cancer].[Article in Hebrew] Harefuah. 2012 Nov;151(11):629-32, 654.

 5. Syed DN, Afaq F, Kweon MH, Hadi N, Bhatia N, Spiegelman VS, Mukhtar H. Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells. Oncogene. 2007 Feb 1;26(5):673-82.

6.  Meng Z, Yan C, Deng Q, Gao DF, Niu XL. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways. Acta Pharmacol Sin. 2013 May 6.

7.  Capini C, Jaturanpinyo M, Chang HI, Mutalik S, McNally A, Street S, Steptoe R, et al. Antigen-specific suppression of inflammatory arthritis using liposomes. J Immunol. 2009 Mar 15;182(6):3556-65

8.  Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, et al. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012;7(3):e33805.

9.  Yin Y, Li W, Son YO, Sun L, Lu J, Kim D, Wang X, et al.  Quercitin protects skin from UVB-induced oxidative damage. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):89-99.

10.  Byun EB, Yang MS, Choi HG, Sung NY, Song DS, Sin SJ, Byun EH. Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression. Biochem Biophys Res Commun. 2013 Feb 22;431(4):698-705. doi: 10.1016/j.bbrc.2013.01.056.

11.  Vaillancourt F, Silva P, Shi Q, Fahmi H, Fernandes JC, Benderdour M.J. Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis.
Cell Biochem. 2011 Jan;112(1):107-17. doi: 10.1002/jcb.22884.

 12. Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X, Zou H, Qiu J. Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts. PLoS One. 2011;6(11):e27081. doi: 10.1371/journal.pone.0027081.

13.  http://nationaleczema.org/eczema/treatment/alternative-therapies/bleach-baths/

14.  http://www.aaaai.org/conditions-and-treatments/library/allergy-library/bleach-bath-recipe-for-skin-conditions.aspx

A big thank you to Dr Schor for allowing me to share his newsletter with all of you.  I particularly enjoyed his description of why he thought bleach might work, as well as the protective supplements that he recommends to help radiation patients.

One More Recommendation

I frequently get asked for natural topical products that help with the discomfort of radiation dermatitis and my followers and clients have had very good results with one particular organic body cream so I like to share it whenever anyone mentions they are about to have radiation treatments.  Despite what the radiation oncologist said earlier in this article, there are things that help quite significantly by protecting the skin and helping it to heal much quicker.

If you would like my help with getting through breast cancer in an inspiring and ultra-healthy way, please sign up for my free e-newsletters and e-book on the right, and/or “like” me on Facebook (MarnieClark.com).  It is my honor and my goal to help you through this so that you emerge from breast cancer feeling better than before, thriving!

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