Tag Archives: help for radiation dermatitis

Kool Relief from Radiation Burns

Kool Relief from Radiation Burns

Ever on the outlook for awesome products for my people going through therapies for breast cancer, I wanted to share with you a unique product  that has recently come to my attention called Kool Relief. It was designed using thermodynamics to ease the damage to skin and underlying tissues that occurs during radiotherapy sessions. First a brief explanation of how radiation burns occur.

How Radiation Burns Occur

Radiotherapy targets cancer cells but can also damage or kill off healthy cells. Radiotherapy is administered in repeated doses over a period of days or weeks, and it can cause problems for the body’s natural repair processes because the skin exposed to the treatment is damaged faster than it can repair itself.

Treatment-related factors that can increase the risk and severity of skin reactions include high cumulative doses, the type of beam used to deliver the radiation, a large treatment field, treatment to areas with skin folds such as under the breast, and delivery together with certain chemotherapy drugs. Moderate to severe reactions can occur toward the end of radiotherapy treatments, weeks after treatment, or with a cumulative radiation dose of 45 to 60 Gray (Gy), a measure of radiation dose.

Radiation Dermatitis Can Occur and it Hurts!

One of the most common side effects of radiation therapy is a skin condition called radiation dermatitis. This can range from a mild, red rash, known as erythema, and/or itchy, peeling or flaking skin known as dry desquamation, to a more severe reaction with blisters and wet, peeling skin, known as moist desquamation. These are a direct result of radiation, the symptoms can take up to 90 days to show up, and they an be quite painful.

Another reaction can occur, called radiation recall, which is a rash that looks like a severe sunburn. Although rare, it occurs when certain types of chemotherapy are given during or subsequent to external beam radiation therapy. The rash appears on the part of the body that received radiation and symptoms may include redness, tenderness, swelling, wet sores, and peeling skin. Typically, these side effects start within days or weeks of radiation therapy. But it can also appear months or years later.

Damage from radiation therapy doesn’t end with the skin. Damage  can also occur along the entire radiation beam’s path, resulting in burns and irritation even to underlying tissues. The burned and irritated tissue generates heat that overtaxes the body’s natural defenses because the body has no natural method of efficiently ridding itself of concentrated heat in tissues. Thermal testing during radiation therapy shows that temperatures can rise 4 to 8.5 degrees in radiation-treated tissue over the patients’ body baseline temperatures.

Traditional Remedies Don’t Work Well

Doctors offer only over-the-counter pain killers and skin care products for radiation burns, many of them full of toxic chemicals. Applying these products to the skin does not provide instant pain relief, and for some the discomfort is excruciating. Even moderate radiation burns can affect a patient’s comfort and quality of life and can be an obstacle to the healing process for an already vulnerable patient. For those unlucky enough to experience severe radiation burns, treatment  may be delayed or changed, and that can compromise the effectiveness of such treatment.

Kool Relief to the Rescue

Kool Relief is the brainchild of inventor Mark LeLong, as the result of having a loved one diagnosed with breast cancer. When she went through radiotherapy and had the resulting radiation dermatitis, Mark decided he could do something about that. He had thorough knowledge of engineering principles and thermodynamics. He researched how best to draw heat from burned tissue, and the most efficient mechanism he found for heat exchange was the heat sink.

A heat sink is best known for its use in computers. It is a passive heat exchanger that transfers the heat generated by an electronic or a mechanical device to a fluid medium, often air or a liquid coolant, where it is dissipated away from the device, thereby allowing regulation of the device’s temperature at optimal levels.

Further study and research found that medical grade aluminum could serve as an efficient heat sink for the human body. Adding the ‘blades’ into the design increased the surface area to carry out heat exchange more rapidly. Mark tested the device with his loved one, and it provided the immediate relief he had hoped for. More volunteers were enlisted, and test results again and again proved the device to be immensely successful.

Kool Relief treats radiation burns directly by employing a basic first aid rule, ‘Cool the burn and avoid the pain.’ Kool Relief’s design forces damaging, painful heat to travel away from tender skin and tissue. Once heat is removed, all that remains is cool comfort. Rapid heat removal saves healthy tissue from damage and  pain.

When the smooth, cupped side of the Kool Relief disk is applied to the burned area, heat is absorbed into the device, passes through the opposite side and dissipates into the air. The disk never gets hot, and the body feels a cool sensation that calms and soothes away pain and discomfort.

The instant Kool Relief touches affected skin, inflammatory heat leaves the body. The skin  and underlying tissues are cooled,  thus sidestepping pain and providing immediate cooling relief.

Kool Relief:

· Provides rapid, completely natural, non-chemical relief for radiation burns on any part of the body;
· Is always cool to the touch without refrigeration, but never cold as ice. If it gets warm you just wave it in the air for a few moments and that cools it down again;
· Is compact and portable, with a discreet design for privacy and ease of use;
· Can be used during and after radiotherapy treatments.

It’s a pretty cool little unit. It’s hand-machined from medical grade aluminum alloy, it’s dishwasher safe, it has no moving parts or electronic parts so it will not need to be repaired, serviced or replaced, it uses no batteries or electricity,  and it’s completely recyclable so it’s environmentally friendly.  All in all, a unique product and people are loving the relief they are getting. For more information, go to the Kool Relief website.

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Unusual Help For Radiation Dermatitis

 

Photo courtesy of morgueFile / cohdra

Image Source: morgueFile / cohdra

Unusual Help For Radiation Dermatitis

Anyone who has gone through radiation therapy for breast cancer understands the meaning of the term “radiation dermatitis”.  By the time the treatment has ended, the patient can have a few nasty side effects ranging anywhere between a mild sunburn to severe and painful ulcerations of the skin.  Some unlucky patients even suffer from radiation necrosis, where the skin of the radiated area actually dies off, creating a hardened and painful area which can take quite some to heal properly.

I don’t share that with you to frighten you, but only to inform because if you are proactive you can definitely ease the discomfort and even hasten your healing time.

What Causes Radiation Dermatitis?

Radiotherapy, also known as radiation oncology, is a form of cancer treatment generally paired with chemotherapy and surgery.  The treatment consists of  beams of radiation being focused onto a tumor (or tumor site if it has been removed), the goal being to kill any malignant cells.  Because the radiation must first pass through the skin, the skin’s quickly dividing cells become damaged as a result.  Radiation dermatitis first presents as a patch of irritation resembling a sunburn. In most cases, healing occurs within weeks of the end of radiotherapy, though some patients report that the skin discoloration remains for many years.

As one radiation oncologist describes it, “Radiation causes skin to fail to reproduce properly, and thus as you ‘use up’ your normal skin, like we all do all day, there are no new layers of skin coming up from the bottom. So eventually the area can ulcerate. This might look like a thermal burn, but it has very little in common with a thermal burn, and the treatments for thermal burns will not help much.” (I’m sorry, I’ve lost the name of the doctor who shared this information.)

Dr Schor Shares Some Research on Bleach Baths for Radiation Dermatitis

Whenever I hear of some new tidbit of information about something assisting radiation dermatitis, I do try to share it.  This time, it comes from Denver-based naturopath, Jacob Schor, ND, FABNO (who is often quoted in this website).  Dr Schor shared this information in a newsletter dated January 14, 2014:

A study published in November 2013 suggests something rather peculiar, that exposure to very dilute laundry bleach may protect against radiation dermatitis.  If you’ve ever followed a cancer patient as they went through radiation treatment, you know what radiation dermatitis is.  Radiation damages the skin, causing what might be less euphemistically described as causing an industrial sunburn, or more accurately as producing human jerky.  Bleach may prevent this from happening, at least to some extent.

A dermatologist named Thomas Leung from Stanford University reported on a pair of trials bathing mice in diluted bleach (hypochlorite). Dilute bleach baths have been used for years to treat eczema, without anyone really knowing why they helped.

One theory was that bleach, being antimicrobial, killed off bacteria that were causing the eczema. A 2009 paper by Amy Paller et al suggests that bleach baths are effective at lowering Staph aureus populations on the skin.[1]    While this sounds like a plausible explanation, there is debate and many consider the bleach dilutions used too weak to have any antibacterial effect.

Really dilute bleach is used to treat eczema, 0.005% sodium hypochlorite, or about one part laundry bleach to 1000 parts water. Leung offers a different explanation for the benefit of bleach.  His research group first examined how diluted bleach affects inflammation; eczema is after all inflammation.

The researchers first examined the effect bleach has on Nuclear factor-kappaB (NF-kB ).  This signaling protein triggers the recruitment of inflammatory cells to sites of infection. Leung’s team exposed human skin cells to the bleach dilution used to treat eczema for an hour and found it blocked NF-kB signaling. The bleach oxidizes the molecule responsible for activating NF-kB and so stops the inflammatory cascade from being initiated. By blocking this activator, the bleach inhibits the NF-kB inflammatory pathway.

This is ever so interesting and opens multiple possibilities.  NF-kB is kind of the common denominator of most inflammatory reactions; it ‘regulates cellular responses to inflammation and aging, and alterations in NF-kB signaling underlie the pathogenesis of multiple human diseases.’

Leung’s team tried dilute bleach on mice to see if it changed radiation dermatitis, as this reaction is instigated by NF-kB. They also tried bleach on the ageing skin of healthy but old mice.

In the radiation experiment, the mice were placed in either a dilute bleach bath or a water bath for 30 minutes daily for ten days prior to radiation treatment. The radiation burns on these ‘bleached’ mice were milder and healed faster than those on the mice who had only been exposed to water baths.

Similar benefits were seen in the old mice.  Daily bleach baths ‘… increased skin cell production resulting in thicker, younger-looking skin than old mice that took plain water baths. In addition, they had lower expression of two genes classically associated with aging.  The effect was short lived, however. The rejuvenated skin returned to its elderly look after about two weeks because the action of bleach on NF-kB is mild, and diminishes with time.’ [2,3]

This might be a surprisingly simple way to reduce radiation dermatitis.  Nasty skin reactions can force postponement of radiation treatment and reduce its effectiveness at preventing cancer recurrence.  Preventing the skin reactions might improve long-term survival.

Bleach may do more than prevent these skin reactions in cancer patients.  NF-kB  ‘plays a critical role in cancer development and progression’ and is a ‘key pathway in activation of immune responses’ and this ‘activation may also affect the cancer’s response to therapy, making it less susceptive to radio and chemo treatment.’ [4]

We already encourage cancer patients to take many of the supplements that lower NF-kB .  These include green tea [5] , curcumin [6,7], quercetin [8-10], nigella sativa, [11] resveratrol  and other polyphenols [12].  A daily dip in the bleach might help cancer patients in other ways.

This study draws my attention because it is so counterintuitive.  It is backwards from what you would think.  Bleach is a nasty caustic oxidant. It should hurt, not help.

One way to understand this is to see this as an example of hormesis. In toxicology, hormesis refers to the phenomenon in which a graph of a substance’s toxic effects takes on a j-shaped or u-shaped curve.    Low doses can sometimes produce the opposite effect of higher doses.  It is like homeopathy’s Law of Similars, just skip the infinitesimal dilutions where there is nothing left except good vibrations..   Concentrated bleach will burn the dickens out of your skin, but in tiny amounts, bleach will protect and heal the skin.

Understanding hormesis may be key to our understanding other therapies we employ in naturopathy.  Many of the phytochemicals we value so much are toxins produced by plants for self-protection.  Curcumin, resveratrol, quercetin and other  of our valued phytochemicals are actually insecticides, anti-fungals and neurotoxins.  Plants make them to ward off predators and kill infectious microbes.  When we use them, it is for their hormetic action.  Exposure triggers an adaptive response in the body recruiting resources to neutralize potential injury.

So what exactly is a 0.005% hypochlorite bleach solution?  Generic bleach is typically about 3-6% sodium hypochlorite.  To reach this dilution one would dilute one-part bleach with about 1,000 parts water.  An average bathtub contains about 100 liters of water, more or less, so a tenth of a liter or 100 ml of bleach, (3.4 oz or about half a cup) would produce approximately this dilution.  Of course bathtubs vary greatly in size, but this gives you an approximate idea.

This is close to the dilution that various websites suggest to treat eczema. The National Eczema Association[13]  and the American Academy of Allergy, Asthma and Immunology both suggest ¼ to ½ cup. [14]

While these data come from animal experiments, there seems to be little risk in translating them into treatment protocols for people.  As mentioned bleach baths are already used to treat eczema.  It seems easy enough to incorporate them into a treatment for cancer patients as well.

References:

1. Huang JT, Abrams M, Tlougan B, Rademaker A, Paller AS. Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity. Pediatrics. 2009 May;123(5):e808-14. doi: 10.1542/peds.2008-2217.

2.   Alyssa Botelho. Vastly diluted bleach may have protective effect on skin. New Scientist:18:28 15 November 2013.

3.  Leung TH, Zhang LF, Wang J, Ning S, Knox SJ, Kim SK. Topical hypochlorite ameliorates NF-κB-mediated skin diseases in mice. J Clin Invest. 2013 Dec 2;123(12):5361-70. Full text: 10.1172/JCI70895

4.  Berkovich L, Ron I, Earon G, Abu-Ghanem S, Rimmon A, Lev-Ari S. [The role of medicinal herbs with anti-inflammatory properties in prevention and treatment of cancer].[Article in Hebrew] Harefuah. 2012 Nov;151(11):629-32, 654.

 5. Syed DN, Afaq F, Kweon MH, Hadi N, Bhatia N, Spiegelman VS, Mukhtar H. Green tea polyphenol EGCG suppresses cigarette smoke condensate-induced NF-kappaB activation in normal human bronchial epithelial cells. Oncogene. 2007 Feb 1;26(5):673-82.

6.  Meng Z, Yan C, Deng Q, Gao DF, Niu XL. Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways. Acta Pharmacol Sin. 2013 May 6.

7.  Capini C, Jaturanpinyo M, Chang HI, Mutalik S, McNally A, Street S, Steptoe R, et al. Antigen-specific suppression of inflammatory arthritis using liposomes. J Immunol. 2009 Mar 15;182(6):3556-65

8.  Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, et al. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012;7(3):e33805.

9.  Yin Y, Li W, Son YO, Sun L, Lu J, Kim D, Wang X, et al.  Quercitin protects skin from UVB-induced oxidative damage. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):89-99.

10.  Byun EB, Yang MS, Choi HG, Sung NY, Song DS, Sin SJ, Byun EH. Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression. Biochem Biophys Res Commun. 2013 Feb 22;431(4):698-705. doi: 10.1016/j.bbrc.2013.01.056.

11.  Vaillancourt F, Silva P, Shi Q, Fahmi H, Fernandes JC, Benderdour M.J. Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis.
Cell Biochem. 2011 Jan;112(1):107-17. doi: 10.1002/jcb.22884.

 12. Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X, Zou H, Qiu J. Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts. PLoS One. 2011;6(11):e27081. doi: 10.1371/journal.pone.0027081.

13.  http://nationaleczema.org/eczema/treatment/alternative-therapies/bleach-baths/

14.  http://www.aaaai.org/conditions-and-treatments/library/allergy-library/bleach-bath-recipe-for-skin-conditions.aspx

A big thank you to Dr Schor for allowing me to share his newsletter with all of you.  I particularly enjoyed his description of why he thought bleach might work, as well as the protective supplements that he recommends to help radiation patients.

One More Recommendation

I frequently get asked for natural topical products that help with the discomfort of radiation dermatitis and my followers and clients have had very good results with one particular organic body cream so I like to share it whenever anyone mentions they are about to have radiation treatments.  Despite what the radiation oncologist said earlier in this article, there are things that help quite significantly by protecting the skin and helping it to heal much quicker.

UPDATE: See my page How To Protect Your Skin During Radiation Treatment for Breast Cancer

If you would like my help with getting through breast cancer in an inspiring and ultra-healthy way, please sign up for my free e-newsletters and e-book on the right, and/or “like” me on Facebook (Marnie Clark, Breast Health Coach).  It is my honor and my goal to help you through this so that you emerge from breast cancer feeling better than before, thriving!